NanoMake - L

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nanomake-L | Microfluidic Platform | Microfluidic Product to produce Nano Particles

nanomake-L™

nanomake L™ is India’s first automated microfluidic platform for precise and reproducible nano-formulation at the lab scale.

nanomake L™ utilizes both, single-use and multi-use microfluidic chips to enable reproducible scale-up of nano formulations, such as mRNA-lipid nanoparticles (LNPs), polymeric nanoparticles, liposomes and emulsions while preserving their critical quality attributes. The instrument is based on controlled microfluidic mixing technology, ensures the production of uniform and reproducible high-quality nanoparticles.

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Technical Data Sheet

Key Differentiators of nanomake-L™

  • Cost-Effective and Locally Manufactured
    nanomake-L™ costs 40-60% less than imported microfluidic systems. Further, it incurs lower maintenance costs due to locally available components and technical support.
  • Fully Automated & Plug-and-Play
    Unlike conventional manual or semi-automated systems, nanomake-L™ operates with zero manual intervention, automating critical parameters such as priming, in-line dilution, flow rate, and mixing ratios.
  • Multi-Use Microfluidic Chips
    Unlike single-use systems, nanomake-L™ offers reusable, customizable microfluidic chips with different internal volumes and Material of Construction (MOC) options, making it adaptable for various applications.
  • Patented Microchannel Design
    Our proprietary architecture enhances precision, ensuring uniform nano-formulation, critical for drug development and delivery
  • Broad Flow Rate Compatibility
    Operates at 100 μL/min to 50 mL/min, enabling lab-scale and scale-up studies.
  • Integrated Wash Program
    The system includes an in-built cleaning mechanism, ensuring chip reusability while reducing cross-contamination and lowering operational costs.
  • Scalability & Flexibility
    Supports multiple syringe sizes (500 μL – 10 mL) and allows for the use of multiple nanomaterials for synthesis of lipid nanoparticles (LNPs), polymeric nanoparticles, and emulsions.

Why nanomake-L™ ?

  • User Friendly

    User Friendly

    Easy workflow, Automated operation build your templates.

  • Reproducibility

    Reproducibility

    No batch-to-batch variations.

  • Nano formulation optimization

    Nano formulation optimization in small volume

    Formulation optimization using low volumes conserves expensive chemicals and minimizes waste.

  • Flexible operation

    Flexible operation

    Wide range of process parameters like flow rate, flow rate ratio, in-line dilution on the same platform.

  • Multiuse
    Microfluidic Chip

    Multiuse
    Microfluidic Chip

    Greener, low wastage.

Features

  • Fully automated operation
  • Multi-use microfluidic chip
  • Wide range of flow rates on single platform
  • Configurable 3 precursor pumps
  • Built in washing program
  • Interchangeable microfluidic chips
  • Easily replaceable 2mL, 15mL and 50 mL sample collection attachments

Specifications

  • Flow rates: 100 μL/min to 50 mL/min
  • Temperature: Ambient to 60°C (optional pre-heater)
  • No. of pumps (precursor): 3
  • Syringe sizes: 500 μL, 1, 2.5, 5, 10 mL
  • Microreactor: Multi-use microreactor
  • Nanomaterial synthesis: Lipid, Polymer, Emulsions, Microspheres
  • Controls: Total flow rate, flow ratio, sample volume, in-line dilution

Products In Pipeline

nanomake P

Dec 2025

nanomake P is a GMP-compliant microfluidic system for seamless scale-up to commercial manufacturing

  • Single-Use Flow Path: Designed for sterile, contamination-free manufacturing
  • Fully Automated Workflow: Regulatory-compliant, high-throughput system ensuring consistent product quality.
  • 21 CFR Compliance: Meets global regulatory standards, making it ideal for clinical and commercial applications
  • Scalability & Customization: Allows seamless scale-up from lab-scale nano-formulations (nanomake-L™) to commercial production

Lipid Mixes for Nucleic Acid Delivery

Oct 2025

Ready-to-use, pre-formulated lipid mixes optimized for efficient mRNA and pDNA delivery, ensuring high encapsulation, stability, and transfection performance.

IVT-mRNA Products

Jan 2026

A range of in-vitro transcribed (IVT) mRNA solutions for advanced research applications, including gene expression monitoring and high-sensitivity reporter assays.